Bioactive 3D Scaffolds for the Delivery of NGF and BDNF to Improve Nerve Regeneration
نویسندگان
چکیده
Peripheral nerve injury is an important cause of disability, that can hinder significantly sensory and motor function. The clinical gold standard for peripheral repair the use autografts, nevertheless, this method has limitations such as donor site morbidity. An emerging alternative to autografts are guide conduits, which used entubulate severed provide guidance directed regeneration tissue. These conduits less effective than enhance their performance incorporation neurotrophins be considered. To enable optimal regeneration, it continuously stimulate neurite outgrowth by designing a delivery system sustained neurotrophins. aim study was develop novel bioactive surface on electrospun fibres supply release heparin bound NGF or BDNF electrostatically immobilised onto amine functionalized encourage Schwann cell migration. characterised XPS analysis ELISA. assess effect fibres, primary chick embryo dorsal root ganglia were used, migration measured. Our results showed significant improvement regarding with growth neurites up 3 mm in 7 days, accompanied cells. We hypothesize physical provided along created stimulatory environment regeneration. achieved immobilising relatively low concentrations (1 ng/ml), provides promising, low-cost, scalable improve current conduits.
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ژورنال
عنوان ژورنال: Frontiers in Materials
سال: 2021
ISSN: ['2296-8016']
DOI: https://doi.org/10.3389/fmats.2021.734683